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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HUWE1 All Species: 22.42
Human Site: T13 Identified Species: 61.67
UniProt: Q7Z6Z7 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z6Z7 NP_113584.3 4374 481891 T13 T K L K K T P T E A P A D C R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001088987 4374 481661 T13 T K L K K T P T E A P A D C R
Dog Lupus familis XP_538052 4375 482124 T13 T K L K K T P T E A P A D C R
Cat Felis silvestris
Mouse Mus musculus Q7TMY8 4377 482644 T13 T K L K K T P T E A P A D C R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923899 4360 479137 T13 S K L K K T P T E A P A D C R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573059 5146 556842 S13 V K L K K G S S E L T A E C R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_500284 4177 465393 S13 A E P S S S S S G S D M P P A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GY23 3681 404981
Baker's Yeast Sacchar. cerevisiae Q03280 3268 374166
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.6 98.7 N.A. 97.7 N.A. N.A. N.A. N.A. N.A. 81.6 N.A. 33.7 N.A. 26.2 N.A.
Protein Similarity: 100 N.A. 99.7 99.1 N.A. 98.6 N.A. N.A. N.A. N.A. N.A. 88.4 N.A. 48.4 N.A. 44.3 N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. N.A. 93.3 N.A. 53.3 N.A. 0 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. N.A. 100 N.A. 66.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.4 21.2 N.A.
Protein Similarity: N.A. N.A. N.A. 41.1 38.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 0 0 0 0 0 56 0 67 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 67 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 12 0 56 0 0 % D
% Glu: 0 12 0 0 0 0 0 0 67 0 0 0 12 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 12 0 0 12 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 67 0 67 67 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 67 0 0 0 0 0 0 12 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 12 0 0 0 56 0 0 0 56 0 12 12 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 67 % R
% Ser: 12 0 0 12 12 12 23 23 0 12 0 0 0 0 0 % S
% Thr: 45 0 0 0 0 56 0 56 0 0 12 0 0 0 0 % T
% Val: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _